Pubmed-entry ::= {
  pmid 9103496,
  medent {
    em std {
      year 1997,
      month 5,
      day 2
    },
    cit {
      title {
        name "Cardiovascular effects of cholecystokinin-4 are mediated by the
 cholecystokinin-B receptor subtype in the conscious guinea pig and dog."
      },
      authors {
        names ml {
          "Fossa AA",
          "DePasquale MJ",
          "Morrone J",
          "Zorn SH",
          "Bryce D",
          "Lowe JA",
          "McLean S"
        },
        affil str "Department of General Pharmacology, Pfizer Central
 Research, Groton, Connecticut 06340, USA."
      },
      from journal {
        title {
          iso-jta "J. Pharmacol. Exp. Ther.",
          ml-jta "J Pharmacol Exp Ther",
          issn "0022-3565",
          name "The Journal of pharmacology and experimental therapeutics"
        },
        imp {
          date std {
            year 1997,
            month 4
          },
          volume "281",
          issue "1",
          pages "180-187",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus pubmed,
              date std {
                year 1997,
                month 4,
                day 1
              }
            },
            {
              pubstatus medline,
              date std {
                year 1997,
                month 4,
                day 1,
                hour 0,
                minute 1
              }
            },
            {
              pubstatus other,
              date std {
                year 1997,
                month 4,
                day 1,
                hour 0,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pubmed 9103496
      }
    },
    abstract "Panicogenic effects in humans of the selective cholecystokinin
 (CCK(B)) receptor agonist, cholecystokinin tetrapeptide (CCK4), have been
 reported to correlate with increases in heart rate (HR) and mean arterial
 pressure (MAP). Previous investigators have demonstrated that the
 nonselective CCK(A) and CCK(B) receptor agonist, sulfated cholecystokinin
 octapeptide, also produces increases in HR and mean arterial pressure. The
 purpose of our study is to determine if the cardiovascular changes induced by
 CCK4 are mediated by the CCK(A) or CCK(B) receptor subtype using selective
 CCK antagonists for both receptor subtypes. The rank order of potency of the
 CCK receptor antagonists affecting CCK4-induced HR and mean arterial pressure
 changes in the guinea pig corresponded to the rank order of potency for
 blockade of the CCK(B) receptor binding in rat cortex, phosphatidyl inositol
 turnover in AR 4-2J rat pancreatoma cells and inhibition of
 pentagastrin-induced acid secretion in the rat. The changes induced by CCK4
 on HR, but not mean arterial pressure, appear to be species dependent as
 reflected by a decrease in the HR in the guinea pig and an increase in the
 dog. Nonetheless, the results from the antagonist studies indicate that the
 cardiovascular responses to CCK4 in both the guinea pig and dog are mediated
 by the CCK(B) receptor subtype.",
    mesh {
      {
        term "Animals"
      },
      {
        term "Blood Pressure",
        qual {
          {
            mp TRUE,
            subh "drug effects"
          }
        }
      },
      {
        term "Dogs"
      },
      {
        term "Gastric Acid",
        qual {
          {
            subh "secretion"
          }
        }
      },
      {
        term "Guinea Pigs"
      },
      {
        term "Heart Rate",
        qual {
          {
            mp TRUE,
            subh "drug effects"
          }
        }
      },
      {
        term "Male"
      },
      {
        term "Phosphatidylinositols",
        qual {
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Rats"
      },
      {
        term "Rats, Sprague-Dawley"
      },
      {
        term "Receptor, Cholecystokinin A"
      },
      {
        term "Receptor, Cholecystokinin B"
      },
      {
        term "Receptors, Cholecystokinin",
        qual {
          {
            mp TRUE,
            subh "drug effects"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Tetragastrin",
        qual {
          {
            mp TRUE,
            subh "pharmacology"
          }
        }
      }
    },
    substance {
      {
        type nameonly,
        name "Phosphatidylinositols"
      },
      {
        type nameonly,
        name "Receptor, Cholecystokinin A"
      },
      {
        type nameonly,
        name "Receptor, Cholecystokinin B"
      },
      {
        type nameonly,
        name "Receptors, Cholecystokinin"
      },
      {
        type cas,
        cit "1947-37-1",
        name "Tetragastrin"
      }
    },
    pmid 9103496,
    pub-type {
      "Journal Article"
    },
    status medline
  }
}

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