Pubmed-entry ::= {
  pmid 22237713,
  medent {
    em std {
      year 2012,
      month 1,
      day 12
    },
    cit {
      title {
        name "Immunohistochemical localization of complement regulatory
 proteins in the human retina."
      },
      authors {
        names ml {
          "Fett AL",
          "Hermann MM",
          "Muether PS",
          "Kirchhof B",
          "Fauser S"
        },
        affil str "Center of Ophthalmology, University of Cologne, Cologne,
 Germany."
      },
      from journal {
        title {
          iso-jta "Histol. Histopathol.",
          ml-jta "Histol Histopathol",
          issn "1699-5848",
          name "Histology and histopathology"
        },
        imp {
          date std {
            year 2012,
            month 3
          },
          volume "27",
          issue "3",
          pages "357-364",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus other,
              date std {
                year 2012,
                month 1,
                day 13,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 1,
                day 13,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 5,
                day 9,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pubmed 22237713
      }
    },
    abstract "Age-related macular degeneration (AMD) is a complex disease.
 Genetic studies have found strong associations between AMD and variants of
 several complement pathway-associated genes. The regulation of the complement
 cascade seems to be critical in the pathogenesis of AMD. In 45 human donor
 eyes immunohistochemistry was performed using antibodies directed against
 major regulators of the complement system: complement factor H (CFH), decay
 accelerating factor (DAF/CD55), complement receptor 1 (CR1/CD35), and
 membrane cofactor protein (MCP/CD46). All eyes were classified in AMD and
 controls. 11 eyes were graded as early AMD. 34 eyes were controls. In all
 eyes staining was found in intercapillary pillars of choroid adjacent to
 Bruch's membrane for CFH, at the basal surface of RPE cells for MCP, and at
 the apical side of the retinal pigment epithelium for CR1. DAF
 immunoreactivity was increased along the inner segments of rod and cone
 photoreceptor cells at the level of the external limiting membrane Labeling
 of soft drusen was found for CFH and CR1. In addition, DAF and CR1 showed
 staining of ganglion cells in all eyes. CFH and particularly MCP showed
 decreased or absent staining in eyes with early AMD adjacent to Bruch's
 membrane. The overlapping expression of regulators at the level of Bruch's
 membrane and the retinal pigment epithelium shows the importance of this site
 for control of the complement system. Decreased and therefore unbalanced
 expression of regulators, as shown in this study for CFH and MCP, may
 ultimately lead to AMD.",
    mesh {
      {
        term "Adult"
      },
      {
        term "Aged"
      },
      {
        term "Antigens, CD46",
        qual {
          {
            subh "analysis"
          }
        }
      },
      {
        term "Antigens, CD55",
        qual {
          {
            subh "analysis"
          }
        }
      },
      {
        term "Case-Control Studies"
      },
      {
        term "Complement Factor H",
        qual {
          {
            subh "analysis"
          }
        }
      },
      {
        term "Complement System Proteins",
        qual {
          {
            mp TRUE,
            subh "analysis"
          }
        }
      },
      {
        term "Germany"
      },
      {
        term "Humans"
      },
      {
        mp TRUE,
        term "Immunohistochemistry"
      },
      {
        term "Macular Degeneration",
        qual {
          {
            mp TRUE,
            subh "immunology"
          },
          {
            subh "pathology"
          }
        }
      },
      {
        term "Middle Aged"
      },
      {
        term "Receptors, Complement 3b",
        qual {
          {
            subh "analysis"
          }
        }
      },
      {
        term "Retina",
        qual {
          {
            mp TRUE,
            subh "immunology"
          },
          {
            mp TRUE,
            subh "pathology"
          }
        }
      },
      {
        term "Young Adult"
      }
    },
    substance {
      {
        type nameonly,
        name "Antigens, CD46"
      },
      {
        type nameonly,
        name "Antigens, CD55"
      },
      {
        type nameonly,
        name "CD46 protein, human"
      },
      {
        type nameonly,
        name "CR1 protein, human"
      },
      {
        type nameonly,
        name "Receptors, Complement 3b"
      },
      {
        type nameonly,
        name "complement factor H, human"
      },
      {
        type cas,
        cit "80295-65-4",
        name "Complement Factor H"
      },
      {
        type cas,
        cit "9007-36-7",
        name "Complement System Proteins"
      }
    },
    pmid 22237713,
    pub-type {
      "Journal Article"
    },
    status medline
  }
}

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