Pubmed-entry ::= {
  pmid 22411238,
  medent {
    em std {
      year 2012,
      month 3,
      day 13
    },
    cit {
      title {
        name "Frontotemporal Lobar Degeneration."
      },
      authors {
        names ml {
          "Premi E",
          "Padovani A",
          "Borroni B"
        },
        affil str "Centre for Ageing Brain and Neurodegenerative Disorders,
 University of Brescia, Brescia, Italy."
      },
      from journal {
        title {
          iso-jta "Adv. Exp. Med. Biol.",
          ml-jta "Adv Exp Med Biol",
          issn "0065-2598",
          name "Advances in experimental medicine and biology"
        },
        imp {
          date std {
            year 2012
          },
          volume "724",
          pages "114-127",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus other,
              date std {
                year 2012,
                month 3,
                day 14,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 3,
                day 14,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 4,
                day 11,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        doi "10.1007/978-1-4614-0653-2_9",
        pubmed 22411238
      }
    },
    abstract "Frontotemporal Lobar Degeneration (FTLD) is an heterogeneous
 neurodegenerative disorder characterized by behaviour and language
 disturbances, associated with degeneration of the frontal and temporal lobes.
 Three different clinical presentations have been described, namely
 behavioural variant Frontotemporal Dementia (bvFTD), Semantic Dementia (SD)
 and Progressive Non-Fluent Aphasia (PNFA). The associated histopathology
 includes different neuropathological hallmarks, the most frequent being
 tau-positive inclusions (FTLD-TAU) or tau-negative and TDP-43 positive
 inclusions (FTLD-TDP). The majority of familial FTLD cases are caused by
 mutations within Microtubule-Associated Protein Tau (MAPT) gene, leading to
 FTLD-TAU, or Progranulin (PGRN) gene, leading to FTLD-TDP. In the last few
 years, imaging, biological and genetic biomarkers have been developed,
 helping in clinical evaluation and diagnostic accuracy. Though current
 pharmacologic interventions are only symptomatic, recent research argues for
 possible disease-modifying strategies in the near future.",
    mesh {
      {
        term "Biological Markers"
      },
      {
        term "Brain",
        qual {
          {
            mp TRUE,
            subh "pathology"
          }
        }
      },
      {
        term "DNA-Binding Proteins",
        qual {
          {
            subh "genetics"
          }
        }
      },
      {
        term "Frontotemporal Lobar Degeneration",
        qual {
          {
            mp TRUE,
            subh "diagnosis"
          },
          {
            subh "epidemiology"
          },
          {
            mp TRUE,
            subh "genetics"
          }
        }
      },
      {
        mp TRUE,
        term "Genetics"
      },
      {
        term "Humans"
      },
      {
        term "Intercellular Signaling Peptides and Proteins",
        qual {
          {
            subh "genetics"
          }
        }
      },
      {
        term "Mutation",
        qual {
          {
            mp TRUE,
            subh "genetics"
          }
        }
      },
      {
        term "Ubiquitin",
        qual {
          {
            subh "metabolism"
          }
        }
      },
      {
        term "tau Proteins",
        qual {
          {
            subh "genetics"
          }
        }
      }
    },
    substance {
      {
        type nameonly,
        name "Biological Markers"
      },
      {
        type nameonly,
        name "DNA-Binding Proteins"
      },
      {
        type nameonly,
        name "GRN protein, human"
      },
      {
        type nameonly,
        name "Intercellular Signaling Peptides and Proteins"
      },
      {
        type nameonly,
        name "MAPT protein, human"
      },
      {
        type nameonly,
        name "Ubiquitin"
      },
      {
        type nameonly,
        name "protein TDP-43"
      },
      {
        type nameonly,
        name "tau Proteins"
      }
    },
    pmid 22411238,
    pub-type {
      "Journal Article",
      "Review"
    },
    status medline
  }
}

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