Pubmed-entry ::= {
  pmid 22610759,
  medent {
    em std {
      year 2012,
      month 5,
      day 21
    },
    cit {
      title {
        name "A latent modeling approach to genotype-phenotype relationships:
 maternal problem behavior clusters, prenatal smoking, and MAOA genotype."
      },
      authors {
        names ml {
          "McGrath LM",
          "Mustanski B",
          "Metzger A",
          "Pine DS",
          "Kistner-Griffin E",
          "Cook E",
          "Wakschlag LS"
        },
        affil str "Psychiatric and Neurodevelopmental Genetics Unit,
 Department of Psychiatry and Center for Human Genetic Research, Massachusetts
 General Hospital/Harvard Medical School, Simches Research Building 6th floor,
 185 Cambridge Street, Boston, MA, 02114, USA, mcgrath@pngu.mgh.harvard.edu."
      },
      from journal {
        title {
          iso-jta "Arch Womens Ment Health",
          ml-jta "Arch Womens Ment Health",
          issn "1435-1102",
          name "Archives of women's mental health"
        },
        imp {
          date std {
            year 2012,
            month 5,
            day 19
          },
          language "ENG",
          pubstatus aheadofprint,
          history {
            {
              pubstatus received,
              date std {
                year 2012,
                month 1,
                day 17
              }
            },
            {
              pubstatus accepted,
              date std {
                year 2012,
                month 4,
                day 23
              }
            },
            {
              pubstatus aheadofprint,
              date std {
                year 2012,
                month 5,
                day 19
              }
            },
            {
              pubstatus other,
              date std {
                year 2012,
                month 5,
                day 22,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 5,
                day 23,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 5,
                day 23,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        doi "10.1007/s00737-012-0286-y",
        pubmed 22610759
      }
    },
    abstract "This study illustrates the application of a latent modeling
 approach to genotype-phenotype relationships and gene x environment
 interactions, using a novel, multidimensional model of adult female problem
 behavior, including maternal prenatal smoking. The gene of interest is the
 monoamine oxidase A (MAOA) gene which has been well studied in relation to
 antisocial behavior. Participants were adult women (N = 192) who were sampled
 from a prospective pregnancy cohort of non-Hispanic, white individuals
 recruited from a neighborhood health clinic. Structural equation modeling was
 used to model a female problem behavior phenotype, which included conduct
 problems, substance use, impulsive-sensation seeking, interpersonal
 aggression, and prenatal smoking. All of the female problem behavior
 dimensions clustered together strongly, with the exception of prenatal
 smoking. A main effect of MAOA genotype and a MAOA x physical maltreatment
 interaction were detected with the Conduct Problems factor. Our phenotypic
 model showed that prenatal smoking is not simply a marker of other maternal
 problem behaviors. The risk variant in the MAOA main effect and interaction
 analyses was the high activity MAOA genotype, which is discrepant from
 consensus findings in male samples. This result contributes to an emerging
 literature on sex-specific interaction effects for MAOA.",
    pmid 22610759,
    pub-type {
      "JOURNAL ARTICLE"
    },
    status publisher
  }
}

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