Pubmed-entry ::= {
  pmid 22285022,
  medent {
    em std {
      year 2012,
      month 1,
      day 30
    },
    cit {
      title {
        name "A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH
 analysis in a Ph+ ALL patient."
      },
      authors {
        names ml {
          "Zhang R",
          "Kim YM",
          "Yang X",
          "Li Y",
          "Li S",
          "Lee JY"
        },
        affil str "Department of Pediatrics, University of Oklahoma Health
 Sciences Center, Oklahoma City, USA."
      },
      from journal {
        title {
          iso-jta "Cancer Genet",
          ml-jta "Cancer Genet",
          issn "2210-7762",
          name "Cancer genetics"
        },
        imp {
          date std {
            year 2011,
            month 12
          },
          volume "204",
          issue "12",
          pages "687-691",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus received,
              date std {
                year 2011,
                month 5,
                day 30
              }
            },
            {
              pubstatus revised,
              date std {
                year 2011,
                month 11,
                day 25
              }
            },
            {
              pubstatus accepted,
              date std {
                year 2011,
                month 11,
                day 28
              }
            },
            {
              pubstatus other,
              date std {
                year 2012,
                month 1,
                day 31,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 1,
                day 31,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 3,
                day 27,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pii "S2210-7762(11)00340-1",
        doi "10.1016/j.cancergen.2011.11.006",
        pubmed 22285022
      }
    },
    abstract "A translocation between chromosomes 19 and 21
 [dic/t(19;21)(p13;v)] is very rare. To date, only three cases of this
 particular chromosomal abnormality have been reported. The translocations in
 these three cases were secondary changes in acute lymphoblastic leukemia
 (ALL) patients with the t(9;22) translocation. The gene(s) at the breakpoints
 of either chromosome 19p13 or 21q have not yet been identified. Here, we
 present a case study of a 21-year-old female with a diagnosis of precursor B
 cell ALL, with the t(9;22) translocation and secondary changes including a
 der(19)t(19;21) and an extra Philadelphia (Ph+) chromosome [der(22)t(9;22)].
 Array comparative genomic hybridization (aCGH) analysis identified UHRF1 and
 NRIP1 as genes that were interrupted at the breakpoints of 19p13.3 and
 21q21.1, and joined together as a possible fusion gene, 5'-NRIP1/UHRF1-3', on
 the derivative chromosome 19. To our knowledge, this is the first description
 of possible genes involved in the unbalanced translocation between
 chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22)
 translocation.",
    mesh {
      {
        term "Adaptor Proteins, Signal Transducing",
        qual {
          {
            mp TRUE,
            subh "genetics"
          }
        }
      },
      {
        term "Adult"
      },
      {
        term "CCAAT-Enhancer-Binding Proteins",
        qual {
          {
            mp TRUE,
            subh "genetics"
          }
        }
      },
      {
        term "Chromosomes, Human, Pair 19"
      },
      {
        term "Chromosomes, Human, Pair 21"
      },
      {
        term "Comparative Genomic Hybridization"
      },
      {
        term "Female"
      },
      {
        term "Humans"
      },
      {
        term "Karyotype"
      },
      {
        term "Karyotyping"
      },
      {
        term "Nuclear Proteins",
        qual {
          {
            mp TRUE,
            subh "genetics"
          }
        }
      },
      {
        mp TRUE,
        term "Oncogene Fusion"
      },
      {
        mp TRUE,
        term "Philadelphia Chromosome"
      },
      {
        term "Precursor Cell Lymphoblastic Leukemia-Lymphoma",
        qual {
          {
            mp TRUE,
            subh "genetics"
          }
        }
      },
      {
        term "Translocation, Genetic"
      }
    },
    substance {
      {
        type nameonly,
        name "Adaptor Proteins, Signal Transducing"
      },
      {
        type nameonly,
        name "CCAAT-Enhancer-Binding Proteins"
      },
      {
        type nameonly,
        name "Nuclear Proteins"
      },
      {
        type nameonly,
        name "UHRF1 protein, human"
      },
      {
        type nameonly,
        name "nuclear receptor interacting protein 1"
      }
    },
    pmid 22285022,
    pub-type {
      "Case Reports",
      "Journal Article"
    },
    status medline
  }
}

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