Pubmed-entry ::= {
  pmid 22423036,
  medent {
    em std {
      year 2012,
      month 3,
      day 16
    },
    cit {
      title {
        name "Regulation of cardiovascular development by adenosine and
 adenosine-mediated embryo protection."
      },
      authors {
        names ml {
          "Rivkees SA",
          "Wendler CC"
        },
        affil str "Department of Pediatrics, Yale Child Health Research
 Center, Yale University School of Medicine, New Haven CT, USA.
 scott.rivkees@yale.edu"
      },
      from journal {
        title {
          iso-jta "Arterioscler. Thromb. Vasc. Biol.",
          ml-jta "Arterioscler Thromb Vasc Biol",
          issn "1524-4636",
          name "Arteriosclerosis, thrombosis, and vascular biology"
        },
        imp {
          date std {
            year 2012,
            month 4
          },
          volume "32",
          issue "4",
          pages "851-855",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus other,
              date std {
                year 2012,
                month 3,
                day 17,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 3,
                day 17,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 5,
                day 15,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus other,
              date std {
                year 2013,
                month 4,
                day 1,
                hour 0,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pii "32/4/851",
        doi "10.1161/ATVBAHA.111.226811",
        pubmed 22423036,
        other {
          db "pmc",
          tag str "PMC3306598"
        },
        other {
          db "mid",
          tag str "NIHMS339609"
        }
      }
    },
    abstract "Few signaling molecules have as much potential to influence the
 developing mammal as the nucleoside adenosine. Adenosine levels increase
 rapidly with tissue hypoxia and inflammation. Adenosine antagonists include
 the methylxanthines caffeine and theophylline. The receptors that transduce
 adenosine action are the A1, A2a, A2b, and A3 adenosine receptors (A1AR,
 A2aAR, A2bAR, and A3AR). We examined how adenosine acts via A1ARs to
 influence embryo development. Transgenic mice were studied along with embryo
 cultures. Embryos lacking A1ARs were markedly growth retarded following
 intrauterine hypoxia exposure. Studies of mice selectively lacking A1AR in
 the heart identify the heart as a key site of adenosine's embryo-protective
 effects. Studies of isolated embryos showed that adenosine plays a key role
 in modulating embryo cardiac function, especially in the setting of hypoxia.
 When pregnant mice were treated during embryogenesis with the adenosine
 antagonist caffeine, adult mice had abnormal heart function. Adenosine acts
 via A1ARs to play an essential role in protecting the embryo against
 intrauterine stress, and adenosine antagonists, including caffeine, may be an
 unwelcome exposure for the embryo.",
    mesh {
      {
        term "Abnormalities, Drug-Induced",
        qual {
          {
            subh "etiology"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Adenosine",
        qual {
          {
            mp TRUE,
            subh "metabolism"
          }
        }
      },
      {
        term "Adenosine A1 Receptor Antagonists",
        qual {
          {
            subh "pharmacology"
          },
          {
            subh "toxicity"
          }
        }
      },
      {
        term "Animals"
      },
      {
        term "Embryo Culture Techniques"
      },
      {
        term "Heart",
        qual {
          {
            subh "drug effects"
          },
          {
            mp TRUE,
            subh "embryology"
          }
        }
      },
      {
        term "Heart Defects, Congenital",
        qual {
          {
            subh "chemically induced"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Mice"
      },
      {
        term "Mice, Transgenic"
      },
      {
        term "Myocardium",
        qual {
          {
            mp TRUE,
            subh "metabolism"
          }
        }
      },
      {
        term "Receptor, Adenosine A1",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "genetics"
          },
          {
            mp TRUE,
            subh "metabolism"
          }
        }
      },
      {
        mp TRUE,
        term "Signal Transduction",
        qual {
          {
            subh "drug effects"
          }
        }
      }
    },
    substance {
      {
        type nameonly,
        name "Adenosine A1 Receptor Antagonists"
      },
      {
        type nameonly,
        name "Receptor, Adenosine A1"
      },
      {
        type cas,
        cit "58-61-7",
        name "Adenosine"
      }
    },
    idnum {
      "1R01-HD056281/HD/NICHD NIH HHS"
    },
    pmid 22423036,
    pub-type {
      "Journal Article",
      "Research Support, N.I.H., Extramural",
      "Review"
    },
    status medline
  }
}

Other elisa kits Products