Pubmed-entry ::= {
  pmid 22556334,
  medent {
    em std {
      year 2012,
      month 5,
      day 17
    },
    cit {
      title {
        name "Macrophage-derived angiopoietin-like protein 2 accelerates
 development of abdominal aortic aneurysm."
      },
      authors {
        names ml {
          "Tazume H",
          "Miyata K",
          "Tian Z",
          "Endo M",
          "Horiguchi H",
          "Takahashi O",
          "Horio E",
          "Tsukano H",
          "Kadomatsu T",
          "Nakashima Y",
          "Kunitomo R",
          "Kaneko Y",
          "Moriyama S",
          "Sakaguchi H",
          "Okamoto K",
          "Hara M",
          "Yoshinaga T",
          "Yoshimura K",
          "Aoki H",
          "Araki K",
          "Hao H",
          "Kawasuji M",
          "Oike Y"
        },
        affil str "Department of Molecular Genetics, Graduate School of
 Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto
 860-8556, Japan.   oike@gpo.kumamoto-u.ac.jp."
      },
      from journal {
        title {
          iso-jta "Arterioscler. Thromb. Vasc. Biol.",
          ml-jta "Arterioscler Thromb Vasc Biol",
          issn "1524-4636",
          name "Arteriosclerosis, thrombosis, and vascular biology"
        },
        imp {
          date std {
            year 2012,
            month 6
          },
          volume "32",
          issue "6",
          pages "1400-1409",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus aheadofprint,
              date std {
                year 2012,
                month 5,
                day 3
              }
            },
            {
              pubstatus other,
              date std {
                year 2012,
                month 5,
                day 5,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 5,
                day 5,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 5,
                day 5,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pii "ATVBAHA.112.247866",
        doi "10.1161/ATVBAHA.112.247866",
        pubmed 22556334
      }
    },
    abstract "OBJECTIVE: Recently, we reported that angiopoietin-like protein
 2 (Angptl2) functions in various chronic inflammatory diseases. In the
 present study, we asked whether Angptl2 and its associated chronic
 inflammation contribute to abdominal aortic aneurysm (AAA). METHODS AND
 RESULTS: Immunohistochemistry revealed that Angptl2 is abundantly expressed
 in infiltrating macrophages within the vessel wall of patients with AAA and
 in a CaCl(2)-induced AAA mouse model. When Angptl2-deficient mice were used
 in the mouse model, they showed decreased AAA development compared with
 wild-type mice, as evidenced by reduction in aneurysmal size, less severe
 destruction of vessel structure, and lower expression of proinflammatory
 cytokines and matrix metalloproteinase-9. However, no difference in the
 number of infiltrating macrophages within the aortic aneurysmal vessel wall
 was observed between genotypes. AAA development was also significantly
 suppressed in wild-type mice that underwent Angptl2-deficient bone marrow
 transplantation. Expression levels of proinflammatory cytokines and
 metalloproteinase-9 in Angptl2-deficient macrophages were significantly
 decreased, and those decreases were rescued by treatment of Angptl2 deficient
 macrophages with exogenous Angptl2. CONCLUSIONS: Macrophage-derived Angptl2
 contributes to AAA development by inducing inflammation and degradation of
 extracellular matrix in the vessel wall, suggesting that targeting the
 Angptl2-induced inflammatory axis in macrophages could represent a new
 strategy for AAA therapy.",
    pmid 22556334,
    pub-type {
      "Journal Article"
    },
    status premedline
  }
}

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