Pubmed-entry ::= {
  pmid 22114968,
  medent {
    em std {
      year 2011,
      month 11,
      day 25
    },
    cit {
      title {
        name "Mannose-binding lectin and the balance between immune protection
 and complication."
      },
      authors {
        names ml {
          "Takahashi K"
        },
        affil str "Department of Pediatrics, Massachusetts General Hospital,
 Harvard Medical School, 55 Fruit Street, GRJ1402, Boston, MA 02114, USA.
 ktakahashi1@partners.org"
      },
      from journal {
        title {
          iso-jta "Expert Rev Anti Infect Ther",
          ml-jta "Expert Rev Anti Infect Ther",
          issn "1744-8336",
          name "Expert review of anti-infective therapy"
        },
        imp {
          date std {
            year 2011,
            month 12
          },
          volume "9",
          issue "12",
          pages "1179-1190",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus other,
              date std {
                year 2011,
                month 11,
                day 26,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2011,
                month 11,
                day 26,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 4,
                day 19,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus other,
              date std {
                year 2012,
                month 10,
                day 1,
                hour 0,
                minute 0
              }
            }
          }
        }
      },
      ids {
        doi "10.1586/eri.11.136",
        pubmed 22114968,
        other {
          db "pmc",
          tag str "PMC3259613"
        },
        other {
          db "mid",
          tag str "NIHMS347924"
        }
      }
    },
    abstract "The innate immune system is evolutionarily ancient and
 biologically primitive. Historically, it was first identified as an element
 of the immune system that provides the first-line response to pathogens, and
 increasingly it is recognized for its central housekeeping role and its
 essential functions in tissue homeostasis, including coagulation and
 inflammation, among others. A pivotal link between the innate immune system
 and other functions is mannose-binding lectin (MBL), a pattern recognition
 molecule. Multiple studies have demonstrated that MBL deficiency increases
 susceptibility to infection, and the mechanisms associated with this
 susceptibility to infection include reduced opsonophagocytic killing and
 reduced activation of the lectin complement pathway. Results from our
 laboratory have demonstrated that MBL and MBL-associated serine protease
 (MASP)-1/3 together mediate coagulation factor-like activities, including
 thrombin-like activity. MBL and/or MASP-1/3-deficient hosts demonstrate in
 vivo evidence that MBL and MASP-1/3 are involved with hemostasis following
 injury. Staphylococcus aureus-infected MBL null mice developed disseminated
 intravascular coagulation, which was associated with elevated blood IL-6
 levels (but not TNF-alpha) and systemic inflammatory responses. Infected MBL
 null mice also develop liver injury. These findings suggest that MBL
 deficiency may manifest as disseminated intravascular coagulation and organ
 failure with infection. Beginning from these observations, this review
 focuses on the interaction of innate immunity and other homeostatic systems,
 the derangement of which may lead to complications in infection and other
 inflammatory states.",
    mesh {
      {
        term "Animals"
      },
      {
        term "Blood Coagulation",
        qual {
          {
            mp TRUE,
            subh "immunology"
          }
        }
      },
      {
        term "Complement Activation",
        qual {
          {
            mp TRUE,
            subh "immunology"
          }
        }
      },
      {
        term "Complement Pathway, Mannose-Binding Lectin",
        qual {
          {
            subh "immunology"
          }
        }
      },
      {
        term "Disease Susceptibility",
        qual {
          {
            subh "immunology"
          }
        }
      },
      {
        term "Disseminated Intravascular Coagulation",
        qual {
          {
            mp TRUE,
            subh "immunology"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Humans"
      },
      {
        mp TRUE,
        term "Immunity, Innate"
      },
      {
        term "Inflammation",
        qual {
          {
            mp TRUE,
            subh "immunology"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Interleukin-6",
        qual {
          {
            subh "biosynthesis"
          },
          {
            subh "immunology"
          }
        }
      },
      {
        term "Mannose-Binding Protein-Associated Serine Proteases",
        qual {
          {
            subh "deficiency"
          },
          {
            subh "genetics"
          },
          {
            mp TRUE,
            subh "immunology"
          }
        }
      },
      {
        term "Mice"
      },
      {
        term "Mice, Knockout"
      },
      {
        term "Opsonin Proteins",
        qual {
          {
            subh "immunology"
          }
        }
      },
      {
        term "Phagocytosis",
        qual {
          {
            subh "immunology"
          }
        }
      },
      {
        term "Staphylococcal Infections",
        qual {
          {
            subh "immunology"
          },
          {
            subh "microbiology"
          }
        }
      },
      {
        term "Staphylococcus aureus",
        qual {
          {
            subh "immunology"
          }
        }
      }
    },
    substance {
      {
        type nameonly,
        name "Interleukin-6"
      },
      {
        type nameonly,
        name "Opsonin Proteins"
      },
      {
        type ec,
        cit "3.4.21.-",
        name "MASP1 protein, human"
      },
      {
        type ec,
        cit "3.4.21.-",
        name "MASP2 protein, human"
      },
      {
        type ec,
        cit "3.4.21.-",
        name "Mannose-Binding Protein-Associated Serine Proteases"
      }
    },
    idnum {
      "U01 AI074503/AI/NIAID NIH HHS"
    },
    pmid 22114968,
    pub-type {
      "Journal Article",
      "Research Support, N.I.H., Extramural",
      "Review"
    },
    status medline
  }
}

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