Pubmed-entry ::= {
  pmid 22506987,
  medent {
    em std {
      year 2012,
      month 4,
      day 17
    },
    cit {
      title {
        name "Melatonin attenuates inflammation and promotes regeneration in
 rabbits with fulminant hepatitis of viral origin."
      },
      authors {
        names ml {
          "Laliena A",
          "Miguel BS",
          "Crespo I",
          "Alvarez M",
          "Gonzalez-Gallego J",
          "Tunon MJ"
        },
        affil str "Institute of Biomedicine (IBIOMED), University of Leon,
 Leon             Centro de Investigacion Biomedica en Red de Enfermedades
 Hepaticas y Digestivas (CIBEREHD)             Department of Animal Health,
 University of Leon, Leon, Spain."
      },
      from journal {
        title {
          iso-jta "J. Pineal Res.",
          ml-jta "J Pineal Res",
          issn "1600-079X",
          name "Journal of pineal research"
        },
        imp {
          date std {
            year 2012,
            month 3,
            day 19
          },
          language "ENG",
          pubstatus aheadofprint,
          history {
            {
              pubstatus other,
              date std {
                year 2012,
                month 4,
                day 18,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 4,
                day 18,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 4,
                day 18,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        doi "10.1111/j.1600-079X.2012.00995.x",
        pubmed 22506987,
        other {
          db "ELocationID doi",
          tag str "10.1111/j.1600-079X.2012.00995.x"
        }
      }
    },
    abstract "  The objective of the present study was to investigate the
 effect of melatonin on the liver inflammatory and regenerative response in an
 animal model of fulminant hepatic failure (FHF) of viral origin. Rabbits were
 experimentally infected with 2 x 10(4)  hemagglutination units of a rabbit
 hemorrhagic disease virus (RHDV) isolate and received melatonin at two
 concentrations of 10 or 20 mg/kg at 0, 12 and 24 hr postinfection. RHDV
 infection induced an inflammatory response, with increased expression of
 toll-like receptor 4, high-mobility group box (HMGB)1, interleukin
 (IL)-1beta, IL-6, tumor necrosis factor-alpha, and C-reactive protein, and
 decreased expression of decay accelerating factor (DAF/CD55). These effects
 were significantly reduced by melatonin. Matrix metalloproteinase-9
 expression was also lowered in melatonin-treated rabbits. RHDV infection
 inhibited the hepatic regenerative/proliferative response, with a reduced
 expression of hepatocyte growth factor (HGF), epidermal growth factor,
 platelet-derived growth factor (PDGF)-B and vascular endothelial growth
 factor and their receptors; these responses were prevented by melatonin
 administration. Melatonin treatment also resulted in reduced expression of
 phosphorylated Janus kinase and enhanced expression of extracellular
 mitogen-activated protein kinase (ERK) and signal transducer and activator of
 transcription (STAT) 3. Our findings show that anti-inflammatory effects and
 stimulation of regenerative mechanisms contribute to the beneficial effects
 of melatonin in rabbits with experimental infection by RHDV and support a
 potential hepatoprotective role of melatonin in FHF.",
    pmid 22506987,
    pub-type {
      "JOURNAL ARTICLE"
    },
    status publisher
  }
}

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