Pubmed-entry ::= {
  pmid 22194111,
  medent {
    em std {
      year 2011,
      month 12,
      day 23
    },
    cit {
      title {
        name "The effects of alpha lipoic acid on cerebral vasospasm following
 experimental subarachnoid hemorrhage in the rabbit."
      },
      authors {
        names ml {
          "Erdi MF",
          "Guney O",
          "Kiyici A",
          "Esen H"
        },
        affil str "M.H. Afsin State Hospital, Department of Neurosurgery,
 Afsin/ Kahramanmaras, Turkey. mfatiherdi@hotmail.com"
      },
      from journal {
        title {
          iso-jta "Turk Neurosurg",
          ml-jta "Turk Neurosurg",
          issn "1019-5149",
          name "Turkish neurosurgery"
        },
        imp {
          date std {
            year 2011
          },
          volume "21",
          issue "4",
          pages "527-533",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus other,
              date std {
                year 2011,
                month 12,
                day 24,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2011,
                month 12,
                day 24,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 4,
                day 25,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        doi "10.5137/1019-5149.JTN .4431-11.1",
        pubmed 22194111,
        other {
          db "ELocationID doi",
          tag str "10.5137/1019-5149.JTN .4431-11.1"
        }
      }
    },
    abstract "AIM: The aim of this study is to determine the effects of a
 strong dithiol     antioxidant, alpha lipoic acid (ALA) on cerebral vasospasm
 following     subarachnoid hemorrhage in a rabbit model. MATERIAL and
 METHODS: Twenty-one New     Zealand white rabbits were assigned to one of
 three groups: group 1 (control),     group 2 (SAH only), group 3 (SAH+ALA).
 ALA was administered (100 mg/kg/day,     single dose, intraperitoneally). The
 rabbits were sacrificed 72 hours after SAH.     The basilar artery lumen
 areas, arterial wall thickness and endothelial     apoptosis in a cross
 section of basilar artery were measured in all groups. The     tissue MDA,
 SOD, GSH-Px levels were also determined. RESULTS: The elevated     tissue MDA
 levels after SAH were significantly reduced by ALA treatment. The     reduced
 tissue SOD and GSH-Px levels after SAH were also elevated by ALA    
 treatment. In the treatment group the average wall thickness and the mean    
 percentages of apoptotic cells (apoptotic index) were reduced and the average
     cross-sectional areas of the basilar artery were increased statistically 
    significantly. CONCLUSION: ALA treatment attenuates the severity of
 cerebral     vasospasm by its strong antioxidant, antivasospastic and
 antiapoptotic     properties. ALA may potentially serve as agents in the
 prevention of cerebral     vasospasm after SAH.",
    mesh {
      {
        term "Animals"
      },
      {
        term "Antioxidants",
        qual {
          {
            mp TRUE,
            subh "pharmacology"
          },
          {
            subh "therapeutic use"
          }
        }
      },
      {
        term "Apoptosis",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Basilar Artery",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "metabolism"
          },
          {
            subh "physiopathology"
          }
        }
      },
      {
        term "Cerebrovascular Circulation",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Disease Models, Animal"
      },
      {
        term "Endothelial Cells",
        qual {
          {
            mp TRUE,
            subh "drug effects"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Free Radicals",
        qual {
          {
            subh "antagonists & inhibitors"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Glutathione Peroxidase",
        qual {
          {
            subh "antagonists & inhibitors"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Hydrogen Peroxide",
        qual {
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Male"
      },
      {
        term "Malondialdehyde",
        qual {
          {
            subh "antagonists & inhibitors"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Muscle, Smooth, Vascular",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "metabolism"
          },
          {
            subh "physiopathology"
          }
        }
      },
      {
        term "Oxidative Stress",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Rabbits"
      },
      {
        term "Subarachnoid Hemorrhage",
        qual {
          {
            subh "complications"
          },
          {
            mp TRUE,
            subh "physiopathology"
          }
        }
      },
      {
        term "Superoxide Dismutase",
        qual {
          {
            subh "antagonists & inhibitors"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Thioctic Acid",
        qual {
          {
            mp TRUE,
            subh "pharmacology"
          },
          {
            subh "therapeutic use"
          }
        }
      },
      {
        term "Treatment Outcome"
      },
      {
        term "Vasodilation",
        qual {
          {
            subh "drug effects"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Vasospasm, Intracranial",
        qual {
          {
            mp TRUE,
            subh "drug therapy"
          },
          {
            subh "etiology"
          },
          {
            mp TRUE,
            subh "physiopathology"
          }
        }
      }
    },
    substance {
      {
        type nameonly,
        name "Antioxidants"
      },
      {
        type nameonly,
        name "Free Radicals"
      },
      {
        type cas,
        cit "542-78-9",
        name "Malondialdehyde"
      },
      {
        type cas,
        cit "62-46-4",
        name "Thioctic Acid"
      },
      {
        type cas,
        cit "7722-84-1",
        name "Hydrogen Peroxide"
      },
      {
        type ec,
        cit "1.11.1.-",
        name "glutathione peroxidase GPX1"
      },
      {
        type ec,
        cit "1.11.1.9",
        name "Glutathione Peroxidase"
      },
      {
        type ec,
        cit "1.15.1.1",
        name "Superoxide Dismutase"
      }
    },
    pmid 22194111,
    pub-type {
      "Journal Article"
    },
    status medline
  }
}

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