Pubmed-entry ::= {
  pmid 21035134,
  medent {
    em std {
      year 2011,
      month 4,
      day 14
    },
    cit {
      title {
        name "MRI quantitative study and pathologic analysis of crush injury
 in rabbit hind limb muscles."
      },
      authors {
        names ml {
          "Zhang LY",
          "Ding JT",
          "Wang Y",
          "Zhang WG",
          "Deng XJ",
          "Chen JH"
        },
        affil str "Center of War Wound and Trauma of PLA, State Key Laboratory
 of Trauma, Burns, and Combined Injury, Research Institute of Surgery/Daping
 Hospital, Third Military Medical University, Chongqing, PR China.
 hpzhangly@163.com"
      },
      from journal {
        title {
          iso-jta "J. Surg. Res.",
          ml-jta "J Surg Res",
          issn "1095-8673",
          name "The Journal of surgical research"
        },
        imp {
          date std {
            year 2011,
            month 5,
            day 15
          },
          volume "167",
          issue "2",
          pages "E357-E363",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus received,
              date std {
                year 2010,
                month 8,
                day 5
              }
            },
            {
              pubstatus revised,
              date std {
                year 2010,
                month 8,
                day 5
              }
            },
            {
              pubstatus accepted,
              date std {
                year 2010,
                month 9,
                day 8
              }
            },
            {
              pubstatus aheadofprint,
              date std {
                year 2010,
                month 10,
                day 19
              }
            },
            {
              pubstatus other,
              date std {
                year 2010,
                month 11,
                day 2,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2010,
                month 11,
                day 3,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2011,
                month 6,
                day 22,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pii "S0022-4804(10)00771-7",
        doi "10.1016/j.jss.2010.09.014",
        pubmed 21035134
      }
    },
    abstract "BACKGROUND: To explore the value of quantitative magnetic
 resonance imaging (i.e., T2 map technique) in the diagnosis of crush injury
 in rabbit hind limb muscles. MATERIALS AND METHODS: We established a rabbit
 hind limb crush injury model and performed examinations on magnetic resonance
 imaging (MRI) (T1WI, T2WI, and T2 map), muscle pathology, serum level of
 muscular troponin (sTnI), and urine myoglobin (Myo) at 1, 3, 7, 14, and 30 d
 after injury to investigate the correlation of MRI, library examination, and
 histopathology. RESULTS: T2WI of the injured muscle showed high signal
 intensity at 1, 3, and 7 d after crush injury and the T2 value continued to
 rise. The pathologic findings of the muscle included swollen and ruptured
 cells, expanded extra-cellular space, inflammatory reactions, and fine muscle
 fiber regeneration. The serum sTnI and urine Myo were high. At 14 d, these
 indices returned to normal gradually. The T2WI changes and T2 value were
 positively associated with the pathological changes of the muscles, serum
 sTnI and urine Myo. However, the signal intensity of T1WI did not vary
 significantly at different time points. CONCLUSION: T2WI and T2 value from T2
 mapping are very useful methods of choice to evaluate the distribution and
 extension of the affected muscles. The high signal intensity on T2WI of the
 affected muscles after crush injury may be due to an increased extracellular
 space, local inflammation, and incomplete muscle fiber regeneration.",
    mesh {
      {
        term "Animals"
      },
      {
        term "Biological Markers",
        qual {
          {
            subh "metabolism"
          }
        }
      },
      {
        term "Hindlimb",
        qual {
          {
            mp TRUE,
            subh "injuries"
          },
          {
            subh "metabolism"
          }
        }
      },
      {
        mp TRUE,
        term "Magnetic Resonance Imaging"
      },
      {
        term "Male"
      },
      {
        term "Models, Animal"
      },
      {
        term "Muscle Fibers, Skeletal",
        qual {
          {
            subh "pathology"
          }
        }
      },
      {
        term "Muscle, Skeletal",
        qual {
          {
            mp TRUE,
            subh "injuries"
          },
          {
            subh "metabolism"
          },
          {
            mp TRUE,
            subh "pathology"
          }
        }
      },
      {
        term "Myoglobinuria",
        qual {
          {
            subh "urine"
          }
        }
      },
      {
        term "Pressure",
        qual {
          {
            mp TRUE,
            subh "adverse effects"
          }
        }
      },
      {
        term "Rabbits"
      },
      {
        term "Sensitivity and Specificity"
      },
      {
        term "Soft Tissue Injuries",
        qual {
          {
            mp TRUE,
            subh "etiology"
          },
          {
            mp TRUE,
            subh "pathology"
          }
        }
      },
      {
        term "Troponin",
        qual {
          {
            subh "blood"
          }
        }
      }
    },
    substance {
      {
        type nameonly,
        name "Biological Markers"
      },
      {
        type nameonly,
        name "Troponin"
      }
    },
    pmid 21035134,
    pub-type {
      "Journal Article",
      "Research Support, Non-U.S. Gov't"
    },
    status medline
  }
}

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