Pubmed-entry ::= {
  pmid 22278982,
  medent {
    em std {
      year 2012,
      month 1,
      day 26
    },
    cit {
      title {
        name "ACP5 (Uteroferrin): Phylogeny of an Ancient and Conserved Gene
 Expressed in the Endometrium of Mammals."
      },
      authors {
        names ml {
          "Padua MB",
          "Lynch VJ",
          "Alvarez NV",
          "Garthwaite MA",
          "Golos TG",
          "Bazer FW",
          "Kalkunte S",
          "Sharma S",
          "Wagner GP",
          "Hansen PJ"
        }
      },
      from journal {
        title {
          iso-jta "Biol. Reprod.",
          ml-jta "Biol Reprod",
          issn "1529-7268",
          name "Biology of reproduction"
        },
        imp {
          date std {
            year 2012,
            month 1,
            day 25
          },
          language "ENG",
          pubstatus aheadofprint,
          history {
            {
              pubstatus other,
              date std {
                year 2012,
                month 1,
                day 27,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 1,
                day 27,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 1,
                day 27,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pii "biolreprod.111.097964",
        doi "10.1095/biolreprod.111.097964",
        pubmed 22278982
      }
    },
    abstract "Type 5 acid phosphatase (ACP5; also known as tartrate-resistant
 acid phosphatase or uteroferrin) is a metalloprotein secreted by the
 endometrial glandular epithelium of pigs, mares, sheep and water buffalo. In
 this paper, we describe the phylogenetic distribution of endometrial
 expression of ACP5 and demonstrate that endometrial expression arose early in
 evolution, i.e., before divergence of prototherian and therian mammals about
 166 million years ago. To determine expression of ACP5 in the pregnant
 endometrium, RNA was isolated from rhesus, mouse, rat, dog, sheep, cow,
 horse, armadillo, opossum and duck-billed platypus.  Results from RT-PCR and
 RNA-Seq experiments confirmed that ACP5 is expressed in all species examined.
  ACP5 was also demonstrated by immunohistochemistry in endometrium of
 marmoset and goat. Alignment of inferred amino acid sequences shows a high
 conservation of ACP5  throughout speciation, with species-specific
 differences most extensive in the N-terminal and C-terminal regions of the
 protein. Analysis by the Selecton program indicated that most of the sites in
 ACP5 are undergoing purifying selection and no sites undergoing positive
 selection were found. In conclusion, endometrial expression of ACP5 is a
 common feature in all orders of mammals and has been subjected to purifying
 selection. Expression of ACP5 in the uterus predates the divergence of
 therians and prototherians.  ACP5 is an evolutionary conserved gene that is
 likely to exert a common function important for pregnancy in mammals using a
 wide range of reproductive strategies.",
    pmid 22278982,
    pub-type {
      "JOURNAL ARTICLE"
    },
    status publisher
  }
}

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