Pubmed-entry ::= {
  pmid 22315656,
  medent {
    em std {
      year 2012,
      month 2,
      day 8
    },
    cit {
      title {
        name "NF-kappaB and Matrix-Dependent Regulation of Osteopontin
 Promoter Activity in Allylamine-Activated Vascular Smooth Muscle Cells."
      },
      authors {
        names ml {
          "Williams ES",
          "Wilson E",
          "Ramos KS"
        },
        affil str "Department of Veterinary Physiology and Pharmacology, Texas
 A&M University, College Station, TX, USA."
      },
      from journal {
        title {
          iso-jta "Oxid Med Cell Longev",
          ml-jta "Oxid Med Cell Longev",
          issn "1942-0994",
          name "Oxidative medicine and cellular longevity"
        },
        imp {
          date std {
            year 2012
          },
          volume "2012",
          pages "496540",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus received,
              date std {
                year 2011,
                month 8,
                day 17
              }
            },
            {
              pubstatus revised,
              date std {
                year 2011,
                month 10,
                day 9
              }
            },
            {
              pubstatus accepted,
              date std {
                year 2011,
                month 10,
                day 9
              }
            },
            {
              pubstatus epublish,
              date std {
                year 2012,
                month 1,
                day 22
              }
            },
            {
              pubstatus other,
              date std {
                year 2012,
                month 2,
                day 9,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2012,
                month 2,
                day 9,
                hour 6,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2012,
                month 2,
                day 9,
                hour 6,
                minute 0
              }
            }
          }
        }
      },
      ids {
        doi "10.1155/2012/496540",
        pubmed 22315656,
        other {
          db "pmc",
          tag str "PMC3270476"
        }
      }
    },
    abstract "Repeated cycles of oxidative injury by allylamine in vivo induce
 a proliferative rat vascular (aortic) smooth muscle cell (vSMC) phenotype
 characterized by matrix-dependent enhancement of mitogenic sensitivity,
 changes in cell surface integrin expression, and osteopontin (opn)
 overexpression. Here, we show that constitutive and mitogen-stimulated
 NF-kappaB DNA binding activity is enhanced in allylamine vSMCs.
 Matrix-specific changes in cellular Rel protein expression were observed in
 allylamine vSMCs. The NF-kappaB DNA binding element located at -1943 in the 5
'-UTR strongly inhibited opn promoter activity in allylamine vSMCs, and this
 response was regulated by the extracellular matrix. Constitutive increases in
 opn promoter activity were only seen when allylamine cells were seeded on a
 fibronectin substrate, and this response was independent of the NF-kappaB DNA
 binding sequence within the regulatory region. Thus, NF-kappaB functions as a
 critical regulator of the allylamine-induced proliferative phenotype in vSMCs.",
    pmid 22315656,
    pub-type {
      "Journal Article"
    },
    status premedline
  }
}

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