Pubmed-entry ::= {
  pmid 19060098,
  medent {
    em std {
      year 2009,
      month 2,
      day 26
    },
    cit {
      title {
        name "Expression patterns and role of prostaglandin-endoperoxide
 synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin
 receptor, peroxisome proliferator-activated receptor delta and retinoid x
 receptor alpha in rat endometrium during artificially-induced decidualization."
      },
      authors {
        names ml {
          "Gillio-Meina C",
          "Phang SH",
          "Mather JP",
          "Knight BS",
          "Kennedy TG"
        },
        affil str "Department of Physiology and Pharmacology, The University
 of Western Ontario, London, Ontario, Canada."
      },
      from journal {
        title {
          iso-jta "Reproduction",
          ml-jta "Reproduction",
          issn "1741-7899",
          name "Reproduction (Cambridge, England)"
        },
        imp {
          date std {
            year 2009,
            month 3
          },
          volume "137",
          issue "3",
          pages "537-552",
          language "eng",
          pubstatus ppublish,
          history {
            {
              pubstatus aheadofprint,
              date std {
                year 2008,
                month 12,
                day 5
              }
            },
            {
              pubstatus pubmed,
              date std {
                year 2008,
                month 12,
                day 9,
                hour 9,
                minute 0
              }
            },
            {
              pubstatus medline,
              date std {
                year 2009,
                month 6,
                day 16,
                hour 9,
                minute 0
              }
            },
            {
              pubstatus other,
              date std {
                year 2008,
                month 12,
                day 9,
                hour 9,
                minute 0
              }
            }
          }
        }
      },
      ids {
        pii "REP-08-0294",
        doi "10.1530/REP-08-0294",
        pubmed 19060098
      }
    },
    abstract "To determine if changes in endometrial expression of the enzymes
 and receptors involved in prostaglandin (PG) synthesis and action might
 provide insights into the PGs involved in the initiation of decidualization,
 ovariectomized steroid-treated rats at the equivalent of day 5 of
 pseudopregnancy were given a deciduogenic stimulus and killed at various
 times up to 32 h thereafter. The expression of PG-endoperoxide synthases
 (PTGS1 and PTGS2), microsomal PGE synthases (PTGES and PTGES2), cytosolic PGE
 synthase (PTGES3), prostacyclin synthase (PTGIS), prostacyclin receptor,
 peroxisome proliferator-activated receptor delta (PPARD) and retinoid x
 receptor alpha (RXRA) in endometrium was assessed by semiquantitative RT-PCR,
 western blot analyses and immunohistochemistry. In addition, to determine
 which PG is involved in mediating decidualization, we compared the ability of
 PGE(2), stable analogues of PGI(2), L165041 (an agonist of PPARD), and
 docasahexanoic acid (an agonist of RXRA) to increase endometrial vascular
 permeability (EVP, an early event in decidualization), and decidualization
 when infused into the uterine horns of rats sensitized for the decidual cell
 reaction (DCR). EVP was assessed by uterine concentrations of Evans blue 10 h
 after initiation of infusions. DCR was assessed by the uterine mass 5 days
 after the initiation of the infusions. Because enzymes associated with the
 synthesis of PGE(2), including PTGS2, are up-regulated in response to a
 deciduogenic stimulus and because PGE(2) was more effective than the PGI(2)
 analogues and PPARD and RXRA agonists in increasing EVP and inducing
 decidualization, we suggest that PGE(2) is most likely the PG involved in the
 initiation of decidualization in the rat.",
    mesh {
      {
        term "Animals"
      },
      {
        term "Base Sequence"
      },
      {
        term "Blotting, Western"
      },
      {
        term "Cytochrome P-450 Enzyme System",
        qual {
          {
            mp TRUE,
            subh "genetics"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "DNA Primers",
        qual {
          {
            subh "genetics"
          }
        }
      },
      {
        term "Dinoprost",
        qual {
          {
            subh "pharmacology"
          }
        }
      },
      {
        term "Dinoprostone",
        qual {
          {
            subh "physiology"
          }
        }
      },
      {
        term "Embryo Implantation",
        qual {
          {
            mp TRUE,
            subh "physiology"
          }
        }
      },
      {
        term "Endometrium",
        qual {
          {
            mp TRUE,
            subh "metabolism"
          }
        }
      },
      {
        term "Female"
      },
      {
        term "Gene Expression"
      },
      {
        term "Immunohistochemistry"
      },
      {
        term "Intramolecular Oxidoreductases",
        qual {
          {
            mp TRUE,
            subh "genetics"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Molecular Sequence Data"
      },
      {
        term "PPAR delta",
        qual {
          {
            subh "genetics"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Pregnancy"
      },
      {
        term "Prostaglandin-Endoperoxide Synthases",
        qual {
          {
            mp TRUE,
            subh "genetics"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Pseudopregnancy",
        qual {
          {
            subh "metabolism"
          }
        }
      },
      {
        term "RNA, Messenger",
        qual {
          {
            subh "analysis"
          }
        }
      },
      {
        term "Rats"
      },
      {
        term "Rats, Sprague-Dawley"
      },
      {
        term "Receptors, Epoprostenol",
        qual {
          {
            subh "genetics"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Retinoid X Receptor alpha",
        qual {
          {
            subh "genetics"
          },
          {
            subh "physiology"
          }
        }
      },
      {
        term "Reverse Transcriptase Polymerase Chain Reaction"
      }
    },
    substance {
      {
        type nameonly,
        name "DNA Primers"
      },
      {
        type nameonly,
        name "PPAR delta"
      },
      {
        type nameonly,
        name "RNA, Messenger"
      },
      {
        type nameonly,
        name "Receptors, Epoprostenol"
      },
      {
        type nameonly,
        name "Retinoid X Receptor alpha"
      },
      {
        type cas,
        cit "363-24-6",
        name "Dinoprostone"
      },
      {
        type cas,
        cit "551-11-1",
        name "Dinoprost"
      },
      {
        type cas,
        cit "9035-51-2",
        name "Cytochrome P-450 Enzyme System"
      },
      {
        type ec,
        cit "1.14.99.1",
        name "Prostaglandin-Endoperoxide Synthases"
      },
      {
        type ec,
        cit "5.3.-",
        name "Intramolecular Oxidoreductases"
      },
      {
        type ec,
        cit "5.3.99.3",
        name "prostaglandin-E synthase"
      },
      {
        type ec,
        cit "5.3.99.4",
        name "prostacyclin synthetase"
      }
    },
    pmid 19060098,
    pub-type {
      "Journal Article",
      "Research Support, Non-U.S. Gov't"
    },
    status medline
  }
}

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